Obesity / Weight Loss

Dynamics of intra-pericardial and extra-pericardial fat tissues during long-term, dietary induced, moderate weight loss

Gal Tsaban, Arik Wolak, Hila Avni-Hassid, Yftach Gepner, Ilan Shelef, Yaakov Henkin, Dan Schwarzfuchs, Noa Cohen, Nitzan Bril, Michal Rein Dana Serfaty, Shira Kenigsbuch, Lilac Tene, Hila Zelicha, Anat Yaskolka-Meir, Oded Komy, Avital Bilitzky, Yoash Chassidim, Uta Ceglarek, Michael Stumvoll, Matthias Blüher , Joachim Thiery, Dror Dicker, Assaf Rudich , Meir J Stampfer, Iris Shai

RCT with 80 participants.  Moderate but persistent dietary-induced weight loss substantially decreased both IPF and EPF volumes.  Reduction of pericardial adipose tissues is independently associated with an improved lipid profile.  The Mediterranean diet, rich in unsaturated fats and restricted carbohydrates, is superior to an LF diet in terms of the IPF burden reduction.

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A very low calorie ketogenic diet improves weight loss and quality of life in patients with adjustable gastric banding.

Taus M , Fumelli D , Busni D , Borroni F , Sebastianelli S , Nicolai G , Nicolai A

Non-randomized 2 arm prospective with 20 participants.  KD can improve the weight loss and quality of life in patients who underwent LAGB and failed at losing more weight allowing a weight loss comparable to that obtained with a further calibration and it is useful to to avoid drastic calibrations and their collateral effects

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Twelve-month outcomes of a randomized trial of a moderate-carbohydrate versus very lowcarbohydrate diet in overweight adults with type 2 diabetes mellitus or prediabetes

Laura R. Saslow, Jennifer J. Daubenmier, Judith T. Moskowitz, Sarah Kim, Elizabeth J. Murphy, Stephen D. Phinney, Robert Ploutz-Snyder, Veronica Goldman, Rachel M. Cox, Ashley E. Mason, Patricia Moran & Frederick M. Hecht

RCT with 34 particpants.  The results suggest that adults with prediabetes or noninsulin-dependent type 2 diabetes may be able to improve glycemic control with less medication by following an ad libitum very low-carbohydrate ketogenic diet compared to a moderate-carbohydrate, calorie-restricted low-fat diet. Additional research should examine both clinical outcomes and adherence beyond 12 months.

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A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes

Amy L McKenzie, PhD ; Sarah J Hallberg, DO, MS ; Brent C Creighton, PhD ; Brittanie M Volk, RD, PhD ; Theresa M Link, RD, CDE ; Marcy K Abner, RD ; Roberta M Glon, RN, BSN ; James P McCarter, MD, PhD ; Jeff S Volek, RD, PhD ; Stephen D Phinney, MD, PhD

This study, non-randomized parallel arm prospective with 262 participants, demonstrates an individualized program delivered and supported remotely that incorporates nutritional ketosis can be highly effective in improving glycemic control and weight loss in adults with T2D while significantly decreasing medication use.

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Long-term effects of a ketogenic diet in obese patients

Hussein M Dashti, MD PhD FICS FACS, Thazhumpal C Mathew, MSc PhD FRCPath, Talib Hussein, MB ChB, Sami K Asfar, MB ChB MD FRCSEd FACS, Abdulla Behbahani, MB ChB FRCS FACSI PhD FICS FACS, Mousa A Khoursheed, MB ChB FRCS FICS, Hilal M Al-Sayer, MD PhD FICS FACS, Yousef Y Bo-Abbas, MD FRCPC, and Naji S Al-Zaid, BSc PhD

To determine the effects of a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated and monounsaturated fat) in obese patients.

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