Exogenous Ketones

Effects of exogenous ketone supplementation on blood ketone, glucose, triglyceride, and lipoprotein levels in Sprague–Dawley rats

Shannon L. Kesl*, Angela M. Poff, Nathan P. Ward1, Tina N. Fiorelli1, Csilla Ari, Ashley J. Van Putten, Jacob W. Sherwood, Patrick Arnold and Dominic P. D’Agostino

Nutritional ketosis induced by the ketogenic diet (KD) has therapeutic applications for many disease states.  We hypothesized that oral administration of exogenous ketone supplements could produce sustained nutritional ketosis (>0.5 mM) without carbohydrate restriction.

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