RCT with 46 participants:  Significant reduction in BMI-Z-score was achieved in both groups during intervention, and was significantly greater for the HPLC (high protein low carbohydrate) group.  Both groups maintained significant BMI-Z reduction at follow-up; changes were not significantly different between groups.  The HPLC diet is a safe and effective option for medically supervised weight loss in severely obese adolescents.

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